在现实设置中跨多个代理的决策同步是有问题的，因为它要求代理等待其他代理人终止和交流有关终止的终止。理想情况下，代理应该学习和执行异步。这样的异步方法还允许暂时扩展的动作，这些操作可能会根据执行的情况和操作花费不同的时间。不幸的是，当前的策略梯度方法不适用于异步设置，因为他们认为代理在每个时间步骤中都同步推理了动作选择。为了允许异步学习和决策，我们制定了一组异步的多代理参与者 - 批判性方法，这些方法使代理可以在三个标准培训范式中直接优化异步策略：分散的学习，集中学习，集中学习和集中培训以进行分解执行。各种现实域中的经验结果（在模拟和硬件中）证明了我们在大型多代理问题中的优势，并验证了我们算法在学习高质量和异步解决方案方面的有效性。

分享自治是指使自治工人能够与人类合作的方法，以提高人类性能。然而，除了提高性能之外，它通常也可能是有益的，代理同时考虑保留用户的经验或合作满意度。为了解决这一额外目标，我们通过约束自主代理的干预次数来研究改进用户体验的方法。我们提出了两种无模型的加强学习方法，可以考虑到干预措施的艰难和软限制。我们表明，我们的方法不仅表现出现有的基线，而且还消除了手动调整黑匣子超参数，以控制援助水平。我们还提供了对干预情景的深入分析，以进一步照亮系统理解。

最先进的无监督的RE-ID方法使用基于内存的非参数软制AX丢失训练神经网络。存储在存储器中的实例特征向量通过群集和更新在实例级别中分配伪标签。然而，不同的簇大小导致每个群集的更新进度中的不一致。为了解决这个问题，我们呈现了存储特征向量的集群对比度，并计算群集级别的对比度损耗。我们的方法采用唯一的群集表示来描述每个群集，从而产生群集级存储字典。以这种方式，可以有效地保持聚类的一致性，在整个阶段，可以显着降低GPU存储器消耗。因此，我们的方法可以解决集群不一致的问题，并且适用于较大的数据集。此外，我们采用不同的聚类算法来展示我们框架的鲁棒性和泛化。与标准无监督的重新ID管道的集群对比的应用达到了9.9％，8.3％，12.1％的显着改善，而最新的无人纯粹无监督的重新ID方法和5.5％，4.8％，4.4％地图相比与市场，公爵和MSMT17数据集上的最先进的无监督域适应重新ID方法相比。代码可在https://github.com/alibaba/cluster-contrast获得。

Although many studies have successfully applied transfer learning to medical image segmentation, very few of them have investigated the selection strategy when multiple source tasks are available for transfer. In this paper, we propose a prior knowledge guided and transferability based framework to select the best source tasks among a collection of brain image segmentation tasks, to improve the transfer learning performance on the given target task. The framework consists of modality analysis, RoI (region of interest) analysis, and transferability estimation, such that the source task selection can be refined step by step. Specifically, we adapt the state-of-the-art analytical transferability estimation metrics to medical image segmentation tasks and further show that their performance can be significantly boosted by filtering candidate source tasks based on modality and RoI characteristics. Our experiments on brain matter, brain tumor, and white matter hyperintensities segmentation datasets reveal that transferring from different tasks under the same modality is often more successful than transferring from the same task under different modalities. Furthermore, within the same modality, transferring from the source task that has stronger RoI shape similarity with the target task can significantly improve the final transfer performance. And such similarity can be captured using the Structural Similarity index in the label space.

Modern deep neural networks have achieved superhuman performance in tasks from image classification to game play. Surprisingly, these various complex systems with massive amounts of parameters exhibit the same remarkable structural properties in their last-layer features and classifiers across canonical datasets. This phenomenon is known as "Neural Collapse," and it was discovered empirically by Papyan et al. \cite{Papyan20}. Recent papers have theoretically shown the global solutions to the training network problem under a simplified "unconstrained feature model" exhibiting this phenomenon. We take a step further and prove the Neural Collapse occurrence for deep linear network for the popular mean squared error (MSE) and cross entropy (CE) loss. Furthermore, we extend our research to imbalanced data for MSE loss and present the first geometric analysis for Neural Collapse under this setting.

In this paper we derive a PAC-Bayesian-Like error bound for a class of stochastic dynamical systems with inputs, namely, for linear time-invariant stochastic state-space models (stochastic LTI systems for short). This class of systems is widely used in control engineering and econometrics, in particular, they represent a special case of recurrent neural networks. In this paper we 1) formalize the learning problem for stochastic LTI systems with inputs, 2) derive a PAC-Bayesian-Like error bound for such systems, 3) discuss various consequences of this error bound.

Denoising Diffusion Probabilistic Models (DDPMs) are emerging in text-to-speech (TTS) synthesis because of their strong capability of generating high-fidelity samples. However, their iterative refinement process in high-dimensional data space results in slow inference speed, which restricts their application in real-time systems. Previous works have explored speeding up by minimizing the number of inference steps but at the cost of sample quality. In this work, to improve the inference speed for DDPM-based TTS model while achieving high sample quality, we propose ResGrad, a lightweight diffusion model which learns to refine the output spectrogram of an existing TTS model (e.g., FastSpeech 2) by predicting the residual between the model output and the corresponding ground-truth speech. ResGrad has several advantages: 1) Compare with other acceleration methods for DDPM which need to synthesize speech from scratch, ResGrad reduces the complexity of task by changing the generation target from ground-truth mel-spectrogram to the residual, resulting into a more lightweight model and thus a smaller real-time factor. 2) ResGrad is employed in the inference process of the existing TTS model in a plug-and-play way, without re-training this model. We verify ResGrad on the single-speaker dataset LJSpeech and two more challenging datasets with multiple speakers (LibriTTS) and high sampling rate (VCTK). Experimental results show that in comparison with other speed-up methods of DDPMs: 1) ResGrad achieves better sample quality with the same inference speed measured by real-time factor; 2) with similar speech quality, ResGrad synthesizes speech faster than baseline methods by more than 10 times. Audio samples are available at https://resgrad1.github.io/.

Deep learning has been widely used for protein engineering. However, it is limited by the lack of sufficient experimental data to train an accurate model for predicting the functional fitness of high-order mutants. Here, we develop SESNet, a supervised deep-learning model to predict the fitness for protein mutants by leveraging both sequence and structure information, and exploiting attention mechanism. Our model integrates local evolutionary context from homologous sequences, the global evolutionary context encoding rich semantic from the universal protein sequence space and the structure information accounting for the microenvironment around each residue in a protein. We show that SESNet outperforms state-of-the-art models for predicting the sequence-function relationship on 26 deep mutational scanning datasets. More importantly, we propose a data augmentation strategy by leveraging the data from unsupervised models to pre-train our model. After that, our model can achieve strikingly high accuracy in prediction of the fitness of protein mutants, especially for the higher order variants (> 4 mutation sites), when finetuned by using only a small number of experimental mutation data (<50). The strategy proposed is of great practical value as the required experimental effort, i.e., producing a few tens of experimental mutation data on a given protein, is generally affordable by an ordinary biochemical group and can be applied on almost any protein.

Recent CLIP-guided 3D optimization methods, e.g., DreamFields and PureCLIPNeRF achieve great success in zero-shot text-guided 3D synthesis. However, due to the scratch training and random initialization without any prior knowledge, these methods usually fail to generate accurate and faithful 3D structures that conform to the corresponding text. In this paper, we make the first attempt to introduce the explicit 3D shape prior to CLIP-guided 3D optimization methods. Specifically, we first generate a high-quality 3D shape from input texts in the text-to-shape stage as the 3D shape prior. We then utilize it as the initialization of a neural radiance field and then optimize it with the full prompt. For the text-to-shape generation, we present a simple yet effective approach that directly bridges the text and image modalities with a powerful text-to-image diffusion model. To narrow the style domain gap between images synthesized by the text-to-image model and shape renderings used to train the image-to-shape generator, we further propose to jointly optimize a learnable text prompt and fine-tune the text-to-image diffusion model for rendering-style image generation. Our method, namely, Dream3D, is capable of generating imaginative 3D content with better visual quality and shape accuracy than state-of-the-art methods.

Deep neural networks (DNNs) are found to be vulnerable to adversarial attacks, and various methods have been proposed for the defense. Among these methods, adversarial training has been drawing increasing attention because of its simplicity and effectiveness. However, the performance of the adversarial training is greatly limited by the architectures of target DNNs, which often makes the resulting DNNs with poor accuracy and unsatisfactory robustness. To address this problem, we propose DSARA to automatically search for the neural architectures that are accurate and robust after adversarial training. In particular, we design a novel cell-based search space specially for adversarial training, which improves the accuracy and the robustness upper bound of the searched architectures by carefully designing the placement of the cells and the proportional relationship of the filter numbers. Then we propose a two-stage search strategy to search for both accurate and robust neural architectures. At the first stage, the architecture parameters are optimized to minimize the adversarial loss, which makes full use of the effectiveness of the adversarial training in enhancing the robustness. At the second stage, the architecture parameters are optimized to minimize both the natural loss and the adversarial loss utilizing the proposed multi-objective adversarial training method, so that the searched neural architectures are both accurate and robust. We evaluate the proposed algorithm under natural data and various adversarial attacks, which reveals the superiority of the proposed method in terms of both accurate and robust architectures. We also conclude that accurate and robust neural architectures tend to deploy very different structures near the input and the output, which has great practical significance on both hand-crafting and automatically designing of accurate and robust neural architectures.